Funded Grants

NHGRI GT Funding

Grant Categories

On this page we have a list of all funded grants available. If you would like to narrow your choices down to relevant categories, please select from the list to your right.

Technology Development Coordinating Center

Project Title Project Number Contact PI / Project Leader Organization Name
Genome Technologies Coordinating Center HG011735 ADAMS, MARK D JACKSON LABORATORY

 

Sequencing Technology Development Awards

(from NIH RePORTER):

Project Title Project Number Contact PI / Project Leader / Other PI or Lead Organization Name Publications
Single-Molecule Electronic Nucleic Acid Sequencing-by-Synthesis Using Novel Tagged Nucleotides and Nanopore Constructs HG010514 JU, JINGYUE;
CHURCH, GEORGE M; KALACHIKOV, SERGEY
COLUMBIA UNIV NEW YORK MORNINGSIDE Visit PubMed
A Unified Nanopore Platform for Direct Sequencing of Individual Full Length RNA Strands Bearing Modified Nucleotides HG010053 AKESON, MARK A UNIVERSITY OF CALIFORNIA SANTA CRUZ Visit PubMed
Improving biological nanopores for precision nucleic acid sequencing using a computational microscope HG011741 AKSIMENTIEV, ALEKSEI;
CHEN, MIN
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN Visit PubMed
Novel sequencing by synthesis chemistry to further reduce the cost of nucleic acid sequencing HG011060 MAZUR, DANIEL JOSEPH ULTIMA GENOMICS, INC. Visit PubMed
Sequencing by Direct Electrical Measurements of Polymerase Fluctuations HG011079 LINDSAY, STUART ARIZONA STATE UNIVERSITY-TEMPE CAMPUS Visit PubMed
Chemically Tuned Silicon Nitride Nanopores for Nucleic Acid Sequencing HG011096 DWYER, JASON RODGER UNIVERSITY OF RHODE ISLAND Visit PubMed
Single-cell direct RNA sequencing using electrical zero-mode waveguides and engineered reverse transcriptases HG011087 WANUNU, MENI NORTHEASTERN UNIVERSITY Visit PubMed
Exploring 3Dpol for RNA sequencing in real time HG011120 HOU, YA-MING THOMAS JEFFERSON UNIVERSITY Visit PubMed
Direct nanopore detection of modified RNA to probe structure and dynamics HG010538 TIMP, WINSTON GEORGE JOHNS HOPKINS UNIVERSITY Visit PubMed
Computational Design Engine for Accurate and Efficient Sequencing of DNA and RNA HG002776 MUTHUKUMAR, MURUGAPPAN UNIVERSITY OF MASSACHUSETTS AMHERST Visit PubMed
Direct Determination of Multiple Specific Forms of DNA Chemical Modifications in Human Genome HG011095 FANG, GANG ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI Visit PubMed
High-accuracy, long-range sequencing for HIV-1 genotyping HG010108 KIM, SANGGU OHIO STATE UNIVERSITY Visit PubMed
Exonuclease Epigenetic Sequencing HG010049 ERVIN, ERIC ELECTRONIC BIOSCIENCES, INC. Visit PubMed
DNA Sequencing with novel 2D FET-nanopore devices HG010536 DRNDIC, MARIJA UNIVERSITY OF PENNSYLVANIA Visit PubMed
LC/MS-Based Direct RNA Sequencing with Concomitant Capability to Sequence Multiple Base Modifications at Single-base Resolution HG011099 ZHANG, SHENGLONG NEW YORK INST OF TECHNOLOGY Visit PubMed
IMPROVING THROUGHPUT OF LONG READS WITH HIGH CONSENSUS BASE ACCURACY TO RESOLVE REPETITIVE DNAS HG010548 MIGA, KAREN HAYDEN UNIVERSITY OF CALIFORNIA SANTA CRUZ Visit PubMed
High Accuracy Nanopore Sequencing HG005115 GUNDLACH, JENS UNIVERSITY OF WASHINGTON Visit PubMed
Nanopore Based Direct BAT-25 Microsatellite Sequencing HG010435 SCHIBEL, ANNA ELECTRONIC BIOSCIENCES, INC. Visit PubMed
Conductance Fluctuations: A New Approach to Sequencing? HG010522 LINDSAY, STUART ARIZONA STATE UNIVERSITY-TEMPE CAMPUS Visit PubMed
RNA Sequencing Via Single Reverse Transcript Assessments HG011070 GERMAN, SEAN ELECTRONIC BIOSCIENCES, INC. Visit PubMed
Novel sequencing by synthesis platform to greatly reduce the cost of nucleic acid sequencing HG010558 PRATT, MARK ROBIN ULTIMA GENOMICS, INC. Visit PubMed
Single-chain MspA for nanopore sequencing of DNA HG010543 NIEDERWEIS, MICHAEL UNIVERSITY OF ALABAMA AT BIRMINGHAM Visit PubMed

 

 

Novel Nucleic Acid Synthesis Technology Development Program

(from NIH RePORTER):

Project Title Project Number Contact PI / Project Leader Organization Name Publications
A low-cost benchtop oligonucleotide synthesizer using inkjet enzymatic DNA synthesis HG011736 HORGAN, ADRIAN DNA SCRIPT Visit PubMed
Enzymatic Synthesis of RNA HG011669 BENNER, STEVEN A; POMERANTZ, RICHARD T FOUNDATION FOR APPLIED MOLECULAR EVOLUTN Visit PubMed
Development of a Fully Enzymatic Oligonucleotide Synthesis Cycle by Engineered Template Independent Polymerases and a Novel Phosphate dNTP Blocking Group HG011679 SAMMOND, DEANNE WALLANDER; PAUL, NATASHA MOLECULAR ASSEMBLIES, INC. Visit PubMed

 

Genomic Technology Development Awards

(from NIH RePORTER):

Project Title Project Number Contact PI / Project Leader Organization Name Publications
Mapping gene-by-environment interactions using multiplexed single cell RNA-sequencing HG011239 YE, CHUN JIMMIE UNIVERSITY OF CALIFORNIA, SAN FRANCISCO Visit PubMed
Integrative single-cell spatial genomic, transcriptomic, and epigenetic imaging in mammalian tissue HG011245 WANG, SIYUAN YALE UNIVERSITY Visit PubMed
A single cell spatial genomics platform for multi-modal characterization of tissue organization HG010647 CHEN, FEI;
MACOSKO, EVAN Z
BROAD INSTITUTE, INC. Visit PubMed
Non-destructive epigenetic sequencing with DNA deaminase enzymes HG010646 KOHLI, RAHUL MANU;
WU, HAO
UNIVERSITY OF PENNSYLVANIA Visit PubMed
On-site, high-fidelity target sequencing and absolute quantitation for HIV-1 surveillance HG010318 KIM, SANGGU OHIO STATE UNIVERSITY Visit PubMed
DNA barcoding via multi-scan and step control in dual-pore tug-of-war HG011236 REISNER, WALTER;
DUNBAR, WILLIAM BRUCE; SLADEK, ROBERT
MCGILL UNIVERSITY Visit PubMed
Epi-seq: Multiplexed ChIP-seq for personalized medicine and drug discovery HG010237 JELINEK, MARY ANNE ACTIVE MOTIF, INC. Visit PubMed
TempO-Seq Profiling of RNA Epitranscriptomic Modifications HG009763 SELIGMANN, BRUCE E. BIOSPYDER TECHNOLOGIES, INC. Visit PubMed
Development of methods for multi-omic analysis of DNA methylation and chromatin architecture in single cells HG010634 ECKER, JOSEPH R;
DIXON, JESSE R
SALK INSTITUTE FOR BIOLOGICAL STUDIES Visit PubMed
Drop-BS: high-throughput single-cell bisulfite sequencing on a microfluidic droplet platform HG010195 LU, CHANG VIRGINIA POLYTECHNIC INST AND ST UNIV Visit PubMed
Orthocoding for Spatial Sequencing HG011231 SALZMAN, JULIA;
FORDYCE, POLLY MORRELL; ROHATGI, RAJAT
STANFORD UNIVERSITY Visit PubMed
Circular RNA as a platform for genome-wide microRNA sponge libraries HG011214 PICKERING, BRIAN FREDERICK CHIMERNA THERAPEUTICS INC. Visit PubMed
Versatile, exponentially scalable methods for single cell molecular profiling HG010632 SHENDURE, JAY ASHOK;
TRAPNELL, BRUCE COLSTON
UNIVERSITY OF WASHINGTON Visit PubMed
Massively Parallel Single Cell Detection of Rare Variants with Split-Pool Combinatorial Indexing HG011229 KENNEDY, SCOTT ROBERT;
SEELIG, GEORG
UNIVERSITY OF WASHINGTON Visit PubMed
AVATAR: highly parallel analysis of variation in transcription factors and their DNA binding sites HG010200 BULYK, MARTHA L BRIGHAM AND WOMEN’S HOSPITAL Visit PubMed
A transposase system for integrative ChIP-exo and ATAC-seq analysis at single-cell resolution HG010211 ZEITLINGER, JULIA STOWERS INSTITUTE FOR MEDICAL RESEARCH Visit PubMed
Programmable RNA-targeting tools HG009761 ZHANG, FENG BROAD INSTITUTE, INC. Visit PubMed
Next-generation Functional Genetic Screening of Un-screenable Traits HG009285 MALI, PRASHANT;
TAMAYO, PABLO ; ZHANG, KUN
UNIVERSITY OF CALIFORNIA, SAN DIEGO Visit PubMed
Arrayed single-cell readout of pooled genetic perturbation libraries HG009283 BLAINEY, PAUL CLARK BROAD INSTITUTE, INC. Visit PubMed
Development of efficient quantitative chromatin profiling in kit and high-throughput formats HG010640 VENTERS, BRYAN J;
KEOGH, MICHAEL-CHRISTOPHER
EPICYPHER, INC. Visit PubMed
Protein tagging at scale to enable functional genomic studies HG011855 CHAVEZ, ALEJANDRO COLUMBIA UNIVERSITY HEALTH SCIENCES Visit PubMed
Nanopore based profiling of epigenetic state HG009190 TIMP, WINSTON GEORGE JOHNS HOPKINS UNIVERSITY Visit PubMed
RNA targeting tools with novel specific RNA-guided RNA-targeting CRISPR effectors HG011857 GOOTENBERG, JONATHAN SAMUEL; ABUDAYYEH, OMAR O MASSACHUSETTS INSTITUTE OF TECHNOLOGY Visit PubMed
Ion Fountain Nanopore Readers for High-Resolution DNA and RNA Sequencing HG011689 WANUNU, MENI NORTHEASTERN UNIVERSITY Visit PubMed
High-throughput development and characterization of compact tools for transcriptional and chromatin perturbations HG011866 BINTU, LACRAMIOARA; BASSIK, MICHAEL C STANFORD UNIVERSITY Visit PubMed
STAMP technology to enable single-cell and isoform-sensitive detection of RBP sites HG011864 YEO, EUGENE WEI-MING UNIVERSITY OF CALIFORNIA, SAN DIEGO Visit PubMed
High-throughput detection of transcriptomic and epitranscriptomic variation and kinetics using MarathonRT HG011868 PYLE, ANNA MARIE; GRAVELEY, BRENTON R YALE UNIVERSITY Visit PubMed
Bacteriophage Mu as Tool to Study Genome Organization in Bacteria and Eukaryotes HG011838 HARSHEY, RASIKA M;FREDDOLINO, PETER L UNIVERSITY OF TEXAS, AUSTIN Visit PubMed
Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurement HG011850 SINCLAIR, DAVID A HARVARD MEDICAL SCHOOL Visit PubMed
A scalable kit-based assay for multi-omic analyses of transcriptional protein binding and chromatin interactions from ultra-low input frozen and FFPE samples at single-cell resolution HG011897 SCHMITT, ANTHONY  ARIMA GENOMICS, INC. Visit PubMed
Development of efficient quantitative chromatin profiling in kit and high-throughput formats HG010640 VENTERS, BRYAN J; KEOGH, MICHAEL-CHRISTOPHER  EPICYPHER, INC. Visit PubMed
A single-strand ligation approach for concomitant DNA and RNA next-generation sequencing from low abundance inputs HG011877 RAO, VARSHA  CLARET BIOSCIENCE, LLC Visit PubMed

 

Supported by

The Technology Development Coordinating Center is supported by NHGRI Project 1U24HG011735-01 and The Jackson Laboratory.