Funded Grants

NHGRI GT Funding

Single-Cell Methods Awards

(from NIH RePORTER):

Project Title Project Number Contact PI / Project Leader Organization Name Publications
Versatile, exponentially scalable methods for single cell molecular profiling HG010632 SHENDURE, JAY ASHOK;
TRAPNELL, BRUCE COLSTON
UNIVERSITY OF WASHINGTON Visit PubMed
Massively Parallel Single Cell Detection of Rare Variants with Split-Pool Combinatorial Indexing HG011229 KENNEDY, SCOTT ROBERT;
SEELIG, GEORG
UNIVERSITY OF WASHINGTON Visit PubMed
Integrative single-cell spatial genomic, transcriptomic, and epigenetic imaging in mammalian tissue HG011245 WANG, SIYUAN YALE UNIVERSITY Visit PubMed
A single cell spatial genomics platform for multi-modal characterization of tissue organization HG010647 CHEN, FEI;
MACOSKO, EVAN Z
BROAD INSTITUTE, INC. Visit PubMed
Development of methods for multi-omic analysis of DNA methylation and chromatin architecture in single cells HG010634 ECKER, JOSEPH R;
DIXON, JESSE R
SALK INSTITUTE FOR BIOLOGICAL STUDIES Visit PubMed
Drop-BS: high-throughput single-cell bisulfite sequencing on a microfluidic droplet platform HG010195 LU, CHANG VIRGINIA POLYTECHNIC INST AND ST UNIV Visit PubMed
Orthocoding for Spatial Sequencing HG011231 SALZMAN, JULIA;
FORDYCE, POLLY MORRELL; ROHATGI, RAJAT
STANFORD UNIVERSITY Visit PubMed
STAMP technology to enable single-cell and isoform-sensitive detection of RBP sites HG011864 YEO, EUGENE WEI-MING UNIVERSITY OF CALIFORNIA, SAN DIEGO Visit PubMed
Tagmentation-based Indexing for Methylation Sequencing as a novel method of high-throughput methylation clock measurement HG011850 SINCLAIR, DAVID A HARVARD MEDICAL SCHOOL Visit PubMed
A scalable kit-based assay for multi-omic analyses of transcriptional protein binding and chromatin interactions from ultra-low input frozen and FFPE samples at single-cell resolution HG011897 SCHMITT, ANTHONY  ARIMA GENOMICS, INC. Visit PubMed
Single-cell direct RNA sequencing using electrical zero-mode waveguides and engineered reverse transcriptases HG011087 WANUNU, MENI NORTHEASTERN UNIVERSITY Visit PubMed
Arrayed single-cell readout of pooled genetic perturbation libraries HG009283 BLAINEY, PAUL CLARK BROAD INSTITUTE, INC. Visit PubMed

 

Supported by

The Technology Development Coordinating Center is supported by NHGRI Project 1U24HG011735-01 and The Jackson Laboratory.