NHGRI Technology Development Coordination

Stimulating an interactive culture among Genome Technology Development grantees that supports greater productivity through collaboration.

Purpose & Goals

Advances in genomic technologies and methods have facilitated research that is producing significant insights into biology and disease. To further these advances, NHGRI supports the Genome Technology program, which aims to accelerate innovation, development, and early dissemination of genomic technologies. The development of completely novel approaches and the refinement of current technologies to achieve orders-of-magnitude improvements are foundational goals of the program. With these goals in mind, the Genome Technology program consists of a growing set of interrelated efforts that enable novel and refined technologies to proceed through discovery and development, towards commercialization and clinical utilization.

Calendar of Events

May 2022

Nanopore Sequencing: From Genomes to Proteomes

Monday May 9, 2022, 10:30am-12:30pm (Eastern)

Please join experts at the NHGRI Nanopore Conference at Northeastern University for a live, virtual mini-conference aimed at understanding state-of-the-art nanopore sequencing technologies. Nanopore sequencing of single molecules of DNA and RNA has shown the world how long read lengths can help in genomics by facilitating alignment, illuminating dark regions of genomes, and resolving isoforms. A panel of speakers will discuss nanopore development and research and its innovative use to improve DNA/RNA sequencing, modified nucleotide detection, and protein sequencing strategies, followed by live Q&A. Registration is free.

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May 2022

Understanding Cells in Context: Spatial Transcriptomics

Monday May 23, 2022, 11am-2pm (Eastern)

Spatial transcriptomics provides the ability to see the comprehensive gene expression patterns of individual cells in the natural context of their locations in tissues. Building on single-cell RNA-seq analysis, spatial transcriptomics is opening new ways to study cellular heterogeneity in cancer, development, and immune responses. NHGRI and the TDCC are hosting a live, virtual Technology Area Forum on spatial transcriptomics that will provide a clear and concise introduction to the current sequencing-and imaging-based methods that are used in spatial gene expression profiling, will give examples of the power of these approaches as well as the challenges, and will discuss how to get started, followed by live Q&A. Featured speakers include Drs. Fei Chen and Evan Macosko (Broad Institute),Julia Salzman (Stanford), and Siyuan (Steven) Wang (Yale). This event is appropriate for both researchers with current interests in genomics as well as learners exploring the field of transcriptomics. Registration is free.

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July 2022

Understanding Recent Advances in Genome Technology Development

Thursday July 7, 2022, 11am-3pm (Eastern)

Recent improvements in the efficiency, accuracy and complexity of genomic analyses have been driven by new technological advances. The objective of this live, virtual symposium is to provide biomedical researchers, learners and providers with a fundamental understanding of how these new technologies are utilized, as well as emerging opportunities and challenges associated with their optimization and use.  Speakers will discuss genomic technologies that include nanopore and epigenetic sequencing as well as multi-omic analyses of genomic structure and function, followed by roundtable discussions and participant Q&A. Registration is free.

Register online >

July 2022

NIH AGTD Meeting

July 12-14, 2022

The 2022 NIH Advanced Genomic Technology Development annual meeting is scheduled for July 12-14, 2022.

Registration is only open to current NHGRI grantees.

Nucleic Acid Sequencing Technology Development

The goal of this initiative is to develop new technologies and improve the quality and efficiency of DNA sequencing and direct RNA sequencing through the support of approaches and instrumentation that will significantly advance the field of genomics.

Genomic Technology Development

This initiative seeks to catalyze the development and advancement of new technologies that can comprehensively analyze genomic features such as methods to evaluate gene regulation and nuclear organization, and the dynamics of genomic features in single and mixed populations of cells (excluding nucleic acid sequencing technologies).

Synthetic Nucleic Acid Technology Development

This initiative is focused on supporting the advancement of novel technologies and methods to inexpensively and accurately synthesize specified sequences of nucleic acids and synthetic constructs at the scale needed for genomics-based research.

The NHGRI Technology Development Coordinating Center will develop an infrastructure to address the need for closer interactions between these efforts. This will enable opportunities for collaboration among grantees, accelerated technology innovation, and improved dissemination of program advances and resources to the broader biomedical research community.


Single-Molecule Protein Sequencing RFA

NHGRI is pleased to provide the following funding announcement for the Single-Molecule Protein Sequencing RFA: The National Human Genome Research Institute (NHGRI) in collaboration with the National Cancer Institute and the National Institute for Allied and Infectious...

Supported by

The Technology Development Coordinating Center is supported by NHGRI Project 1U24HG011735-01 and The Jackson Laboratory.